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Abstract #4211

Quantification of multi-organ iron overload using R2* mapping in patients with transfusion-dependent diseases

Xiaonan Wang1, Tongtong Sun1, Jinxia Zhu2, Stephan Kannengiesser3, and Hongyan Ni4
1Tianjin Medical University, Tianjin, China, 2Siemens Healthineers Ltd., Beijing, China, 3Siemens Healthcare GmbH, Erlangen, Germany, 4Tianjin First Central Hospital, Tianjin, China


We used R2* mapping to assess iron overload in multiple organs of patients with transfusion-dependent diseases and related the R2* values to transfusion volumes and serum ferritin (SF) levels. The organs assessed included the liver, spleen, pancreas, vertebral bone marrow, and myocardium. The results showed a correlation between the R2* values of multiple organs and between the R2* values of some organs and transfusion volumes. This study revealed differences in the distribution of iron overload in various organs and suggested that transfusion volumes could be used to predict the degree of liver iron overload in patients with transfusion-dependent diseases.

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