To determine the feasibility of multi-frequency MRE for assessing pancreatic stiffness in healthy volunteers and patients with pancreatic adenocarcinoma (PDAC).A total of 40 healthy volunteers and 10 patients with PDAC were prospectively recruited between March 2020 and October 2021.Each volunteer and patient underwent 3.0-T pancreatic MRE at frequencies of 30Hz, 40Hz, 60Hz, 80Hz and 100Hz.Shear stiffness of healthy pancreas and PDAC, pancreatic width and volume, waist circumference, and wave distance were measured. Image quality assessment was performed according to image quality score (IQS: 1~4，≥3 considered qualified).
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