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Abstract #4263

Can combined DWI, IVIM and DKI better differentiate malignant from benign breast lesions with TIC type II?

Wang Hongjie1, Wang Weiwei2, Dou Weiqiang3, Lv Siqiang1, Zhu Laimin2, Chen Yueqin2, and Sun Zhanguo2
1Clinical Medical College of Jining Medical University, Jining, China, 2Department of Medical Imaging, Affiliated Hospital of Jining Medical University, Jining, China, 3MR Research China, GE Healthcare, Beijing, China

Synopsis

Accurate preoperative prediction of benign and malignant breast lesions is essential in clinical practice. Currently, the diagnostic specificity of DCE-MRI is relatively low for breast lesions with time-intensity-curve (TIC) type-II. Different diffusion-weighted models, including mono-exponential diffusion-weighted imaging (DWI), intravoxel-incoherent-motion diffusion-weighted imaging (IVIM) and diffusion kurtosis imaging (DKI), have been previously reported effective in the differential diagnosis of overall breast lesions. In this study, we found that, compared with DWI alone, combined DWI, IVIM and DKI can better differentiate malignant from benign breast TIC type-II lesions, with IVIM parameter of D and DKI parameter of MK as demonstrated independent influencing factors.

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