Accurate preoperative prediction of benign and malignant breast lesions is essential in clinical practice. Currently, the diagnostic specificity of DCE-MRI is relatively low for breast lesions with time-intensity-curve (TIC) type-II. Different diffusion-weighted models, including mono-exponential diffusion-weighted imaging (DWI), intravoxel-incoherent-motion diffusion-weighted imaging (IVIM) and diffusion kurtosis imaging (DKI), have been previously reported effective in the differential diagnosis of overall breast lesions. In this study, we found that, compared with DWI alone, combined DWI, IVIM and DKI can better differentiate malignant from benign breast TIC type-II lesions, with IVIM parameter of D and DKI parameter of MK as demonstrated independent influencing factors.
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