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Abstract #4274

Mean Apparent Propagator-MRI: A Novel Diffusion-Based Approach for Quantitative Assessment of Tumor-Stromal Ratio in Breast Carcinoma

Xiang Zhang1, Wei Jiang1, Mengzhu Wang2, Zehong Yang1, Xu Yan2, Guang Yang3, Chunping Mao1, and Jun Shen1
1Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China, 2MR Scientific Marketing, Siemens Healthineers, Guangzhou, China, 3Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronic Science, East China Normal University, Shanghai, China


Mean apparent propagator (MAP)-MRI establishes a robust analytical framework based on the random motion distribution of natural water molecules. This study investigated the application of quantitative parameters derived from MAP-MRI in patients with breast cancer and determined whether MAP-MRI can be adopted as a better method than apparent diffusion coefficient (ADC) from conventional DWI to preoperative diagnosis tumor-stromal ratio. The results suggested that quantitative assessment with MAP-MRI showed superior predictive performance than conventional DWI for preoperative diagnosis of tumor-stromal ratio in patients with breast cancer.

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