To date, great efforts have been made to investigate the performance of APT imaging in breast cancer diagnosis and prognosis, but with discrepant findings. Hence, this study aims to investigate the diagnostic performance and association of APT imaging with clinical-pathologic characteristics of breast cancer in a relatively large cohort of patients at 3T. Results showed significantly higher APTw signals in malignant lesions than that in benign ones, and high histologic grade, T stage and proliferation Ki-67 index in breast cancer patients. The results confirm the usefulness of APT imaging in the differentiation of lesion malignancy and the prediction of prognosis.
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