Breast amide proton transfer imaging at 3T: diagnostic performance and correlation with pathologic characteristics
Zhou Liu1, Jie Wen1, Meng Wang1, Ya Ren1, Qian Yang1, Long Qian2, Honghong Luo1, Cuiju He1, Yin Wu3, and Dehong Luo1
1National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China, 2MR Research, GE Healthcare, Beijing, China, 3Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
To date, great efforts have been made to investigate the performance of APT imaging in breast cancer diagnosis and prognosis, but with discrepant findings. Hence, this study aims to investigate the diagnostic performance and association of APT imaging with clinical-pathologic characteristics of breast cancer in a relatively large cohort of patients at 3T. Results showed significantly higher APTw signals in malignant lesions than that in benign ones, and high histologic grade, T stage and proliferation Ki-67 index in breast cancer patients. The results confirm the usefulness of APT imaging in the differentiation of lesion malignancy and the prediction of prognosis.
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