Abstract #4276

Breast amide proton transfer imaging at 3T: diagnostic performance and correlation with pathologic characteristics

Zhou Liu¹, Jie Wen¹, Meng Wang¹, Ya Ren¹, Qian Yang¹, Long Qian², Honghong Luo¹, Cuiju He¹, Yin Wu³, and Dehong Luo¹

¹National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China, ²MR Research, GE Healthcare, Beijing, China, ³Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China

Synopsis

To date, great efforts have been made to investigate the performance of APT imaging in breast cancer diagnosis and prognosis, but with discrepant findings. Hence, this study aims to investigate the diagnostic performance and association of APT imaging with clinical-pathologic characteristics of breast cancer in a relatively large cohort of patients at 3T. Results showed significantly higher APTw signals in malignant lesions than that in benign ones, and high histologic grade, T stage and proliferation Ki-67 index in breast cancer patients. The results confirm the usefulness of APT imaging in the differentiation of lesion malignancy and the prediction of prognosis.

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