This study aimed to explore the value of histogram analysis of apparent diffusion coefficient (ADC) maps for whole-body tumor load(WBTL) in predicting and evaluating the treatment response based on International Myeloma Working Group (IMWG) 2016 consensus criteria in patients with multiple myeloma (MM).Histogram analysis of ADC maps extracted eight parameters: mean, median, standard-deviation, entropy, skewness, kurtosis, ADC_5%, and ADC_95%. Seven parameters at baseline were significantly associated with therapy response. Three parameters in treatment percentage change were significantly associated with therapy response. ADC histogram analysis may be considered as an adjunct tool to the MM therapy response evaluation and prediction.
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