Abstract #4294

Correlation between changes of pelvic bone marrow fat content and hematological toxicity in concurrent chemoradiotherapy for cervical cancer

XIAOHANG QIN^1,2, CONG WANG³, and YONG YIN²

¹Department of Graduate, Shandong First Medical University and Shandong Academy of Medical Sciences, Shandong Ji’ nan, China, ²Department of Radiation Physics, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Shandong Ji’ nan, China, ³Department of Fourth Ward of Gynecological Tumor, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Shandong Ji’ nan, China

Synopsis

Bone marrow is a heterogeneous mixed tissue, which can be divided into red bone marrow with hematopoietic activity and yellow bone marrow with high fat content. Concurrent chemoradiotherapy can induce red bone marrow transfer into yellow bone marrow, increasing the bone marrow fat content and inhibiting hematopoietic function. The study used the MRI IDEAL IQ sequence to quantify the changes of pelvic bone marrow fat content receiving different doses of concurrent chemoradiotherapy for cervical cancer, and to determine associations with peripheral blood cell counts.

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