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Abstract #4323

Dynamic quantitative T1 mapping (dyQT1) series for quantitative DCE imaging using variable flip angle method

Qing Li1, Xinyu Song2, Jienan Wang2, Caixia Fu3, Yi Sun1, and Yuehua Li2
1MR Collaborations, Siemens Healthineers Ltd., Shanghai, China, 2Institute of Diagnostic and Interventional Radiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China, 3MR Application Development, Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China


In this work, a new acquisition scheme is proposed for directly measuring the continuous quantitative T1 changes during the contrast enhancement. By alternatively changing the flip angles from phase to phase, the temporal resolution of T1 mapping could be the same as conventional DCE (conv-DCE) imaging, i.e., 4.36 s in our experiments. The dynamic quantitative T1 mapping (dyQT1) DCE method were validated on animal study (rabbit with VX2 tumor), and compared with conv-DCE. The preliminary results showed dyQT1-DCE was more time efficient without native T1 scans and higher sensitivity in the detection of tumor than conv-DCE.

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