Abstract #4323

Dynamic quantitative T1 mapping (dyQT1) series for quantitative DCE imaging using variable flip angle method

Qing Li¹, Xinyu Song², Jienan Wang², Caixia Fu³, Yi Sun¹, and Yuehua Li²

¹MR Collaborations, Siemens Healthineers Ltd., Shanghai, China, ²Institute of Diagnostic and Interventional Radiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China, ³MR Application Development, Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China

Synopsis

In this work, a new acquisition scheme is proposed for directly measuring the continuous quantitative T1 changes during the contrast enhancement. By alternatively changing the flip angles from phase to phase, the temporal resolution of T1 mapping could be the same as conventional DCE (conv-DCE) imaging, i.e., 4.36 s in our experiments. The dynamic quantitative T1 mapping (dyQT1) DCE method were validated on animal study (rabbit with VX2 tumor), and compared with conv-DCE. The preliminary results showed dyQT1-DCE was more time efficient without native T1 scans and higher sensitivity in the detection of tumor than conv-DCE.

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