Earlier diagnosis of non-alcoholic fatty liver disease (NAFLD) becomes important to prevent the disease progression. Recently, a low-cost portable MR system was developed as a point-of-care screening tool for in vivo liver fat quantification. However, the subcutaneous fat may confound the live fat quantification, particularly in the NAFLD susceptible population. In this work, we propose a novel RF coil design composed of a main target coil sandwiching a set of “saturation” coil to improve human liver fat quantification. We demonstrate the capability and effectiveness of the novel RF design in phantom experiments as well as in-vivo liver scans.