Abstract #4381

Myelin Water Imaging in an HIV Population at Risk of Cerebral Small Vessel Disease

Md Nasir Uddin¹, Abrar Faiyaz², Alan Finkelstein³, and Giovanni Schifitto^1,2

¹Department of Neurology, University of Rochester, Rochester, NY, United States, ²Department of Electrical and Computer Engineering, University of Rochester, Rochester, NY, United States, ³Department of Biomedical Engineering, University of Rochester, Rochester, NY, United States

Synopsis

HIV-infected individuals are at increased risk of developing cerebral small vessel disease (CSVD). Myelin damage is a feature in CSVD, and can be quantified using myelin water imaging. In this work, we investigated if MWI can be used to quantify myelin related changes in white matter in an HIV cohort at risk of CSVD. Our results lend support to the use of MHI to track myelin related abnormalities in the white matter.

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