R2* changes reflect the kinetics of formalin-based penetration and fixation in post-mortem tissue
Azadeh Nazemorroaya1, Ali Aghaeifar2, Hildegard Schulz3, Klaus Scheffler 3,4, Thomas Shiozawa-Bayer5, Bernhard Hirt5, and Gisela Hagberg3,4
1High Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, 2Wellcome Centre for Human Neuroimaging, London, United Kingdom, 3High Field Magnetic Resonance,, Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, 4Biomedical Magnetic Resonance, University Hospital Tuebingen, Tuebingen, Germany, 5Clinical Anatomy, University Hospital Tübingen, Tuebingen, Germany
Post-mortem brain MRI can yield valuable information. However, tissue preservation requires substitution of the CSF-fluid by fixation agents, which is time-consuming for large samples. R2* maps, dominated by R2-effects, were measured at several timepoints during fixation of pig-brain tissue samples using formalin-based fixatives.
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