Single-shot simultaneous T2* mapping and QSM using overlapping-echo acquisition for quantitative structural and functional MRI
Qinqin Yang1, Lingceng Ma1, Shuhui Cai1, Hongjian He2, Zhong Chen1, Jianhui Zhong2,3, and Congbo Cai1
1Department of Electronic Science, Xiamen University, Xiamen, China, 2Center for Brain Imaging Science and Technology, College of Biomedical Engineering and Instrumental Science, Zhejiang University, Zhejiang, China, 3Department of Imaging Sciences, University of Rochester, Rochester, NY, United States
A quantitative magnetic resonance imaging (MRI) sequence GRE-MOLED based on overlapping-echo detachment is implemented to simultaneously achieve distortion-free T2* mapping and quantitative susceptibility mapping (QSM) in a single shot. The accuracy of quantitative structural MRI results is verified by comparison with the results from multi-shot method in in-vivo experiments. We also evaluate the technique through a statistical analysis of fMRI experiments with vision and motion tasks and demonstrate that it achieves higher BOLD sensitivity than conventional method.
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