Prostate cancer (PCa) detection by an automated deep-learning computer-aided diagnosis (DL-CAD) system using advanced zoomed diffusion-weighted imaging (z-DWI) and full-field-of-view DWI (f-DWI) were compared. The DL-CAD system using z-DWI performed significantly better for PCa detection accuracy per patient (AUC: 0.937 vs. 0.871; P=0.002) and had significantly higher PCa lesion detection accuracy per lesion compared to f-DWI (AUC: 0.912 vs. 0.833; P=0.003). Given this, use of z-DWI can improve the performance of the DL-CAD system for PCa detection.
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