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Abstract #4412

Quantitative mapping of Gd-DOTA accumulation in mouse brain by MRI after intraperitoneal administration - Validation by mass spectroscopy.

Anthony Tessier1, Anthony Ruze1, Emilien Royer1, Monique Bernard1, Angele Viola1, and Teodora-Adriana Perles-Barbacaru1
1CRMBM UMR 7339, Aix Marseille University, CNRS, Marseille, France


Maps of the contrast agent concentration over time in mouse brains upon intraperitoneal administration were obtained by a dynamic MRI technique. The mice had different degrees of contrast agent accumulation clearly distinguishable on the maps with a particular distribution resembling the pathways of the glymphatic system. The average brain concentration computed 2 hours post contrast agent administration correlates with the gadolinium dosage in the brain by inductively coupled plasma mass spectroscopy proving that quantification is feasible although the signal analysis can be improved.

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