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Abstract #4447

Simultaneous estimation of longitudinal relaxation time and intracellular water lifetime using Active Contrast Encoding MRI

Jin Zhang1, Karl Kiser1, Ayesha Bharadwaj Das1, Sawwal Qayyum1, and Gene Kim1
1Weill Cornell Medical College, New York, NY, United States


Dynamic contrast enhanced (DCE)-MRI can be used as a tool to measure intracellular water lifetime (τi) in tumor cells which can be used as a biomarker for tumor aggressiveness and treatment response. Contrast kinetic model analysis in DCE-MRI requires accurate pre-contrast T1 measurement. We used multiple flip angles for active contrast encoding of both T1 and τi during dynamic data acquisition with one injection. The present study demonstrates the feasibility of measuring T1 and τi simultaneously from the active contrast encoding (ACE) MRI data. ACE-MRI also reduces the scan time by eliminating the need of separate pre-contrast T1 measurement.

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