Dynamic contrast enhanced (DCE)-MRI can be used as a tool to measure intracellular water lifetime (τi) in tumor cells which can be used as a biomarker for tumor aggressiveness and treatment response. Contrast kinetic model analysis in DCE-MRI requires accurate pre-contrast T1 measurement. We used multiple flip angles for active contrast encoding of both T1 and τi during dynamic data acquisition with one injection. The present study demonstrates the feasibility of measuring T1 and τi simultaneously from the active contrast encoding (ACE) MRI data. ACE-MRI also reduces the scan time by eliminating the need of separate pre-contrast T1 measurement.
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