Abstract #4449

Quantitative Susceptibility Mapping for Chamber Blood Oxygenation in Pulmonary Hypertension: Validation using Right Heart Catheterization

Jiahao Li^1,2, Katherine Tak³, Rachel Meier³, Pablo Villar-Calle³, Justin Johannesen³, Jiwon Kim³, Yi Wang^1,2, Jonathan W. Weinsaft³, and Pascal Spincemaille²

¹Biomedical Engineering, Cornell University, New York, NY, United States, ²Radiology, Weill Cornell Medicine, New York, NY, United States, ³Medicine, Weill Cornell Medicine, New York, NY, United States

Synopsis

Pulmonary hypertension (PH) is a progressive and life shortening disorder with increased differential blood oxygen saturation (ΔSaO₂) between right and left heart. In this prospective study, we acquired cardiac QSM from patients undergoing clinically indicated right heart catheterization (RHC) for assessment of known or suspected PH. ΔSaO₂ estimated from QSM aligned well with RHC oxygenation data, showing QSM as a non-invasive CMR technique can be applied to clinically evaluate heart chamber oxygenation quantification in PH.

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