In this study, we used a newly developed tri-frequency RF surface coil that enables 1H MRI and interleaved 2H/17O MRS measurements to simultaneously assess cerebral glucose and oxygen metabolism, cerebral blood flow and oxygen extraction fraction in rat brain at 16.4T with administration of 2H-labeled glucose and 17O-labeled oxygen gas. Our results demonstrate that this approach can capture the activities of major pathways relevant to glucose and oxygen metabolism and perfusion in the same brain at the same time, thereby provide comprehensive information crucial for understanding the metabolic and vascular coupling or uncoupling relationship in healthy and diseased brains.
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