Average Saturation Efficiency Filter (ASEF) is a fast and intuitive technique for achieving CEST imaging with improved sensitivity removing fast exchanges and semi-solid MT background with minimal loss to sensitivity. Our results in MCAO rodents showed that it can detect the ischemic lesion from CEST signal contrasts at 3.6, 2.6, and 2 ppm which may provide different metabolic-related information with higher sensitivity to 3-point measurement at 3.6 ppm and comparable contrast. Its low requirement on number of imaged signals also opens up possibilities for dynamic imaging or signal averaging.
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