Major depressive disorder severity is associated with limbic systems grey matter volumetric reductions, while for cerebral small vascular disease (CSVD) patients with mild to moderate depression the pathological mechanism needs to be future investigated. Diffusion kurtosis imaging (DKI) is an advanced diffusion model that characterizes water diffusion process as non-Gaussian distribution. DKI parameters are highly sensitive to the micro-environment of tissues, especially for the anisotropic structure. This study aimed to investigate the structure changes of limbic systems in patients with cerebral small vascular disease (CSVD) induced mild to moderate depression by applying diffusion kurtosis imaging.
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