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Abstract #4468

Pericarotid fat density was associated with carotid plaque vulnerability, especially IPH and TRFC

Miao Yu1, Yankai Meng1, Beiru Wang1, Yaqiong Ge2, and Kai Xu1
1the Affiliated Hospital of Xuzhou Medical University, Xuzhou, China, 2GE Healthcare´╝îPrecision health institution´╝îChina., Shanghai, China

Synopsis

Inflammation play important roles in the vulnerability of atherosclerotic plaque. Pericoronary fat is associated with coronary heart disease and high-risk plaque, however the value of pericarotid fat density (PFD) remains uncertain. We evaluated the association between PFD on computed tomography angiography (CTA), with the vulnerable composition of carotid plaques. We found that the PFD was independently associated with vulnerability of carotid plaque especially for IPH and TRFC, suggesting that pericarotid fat tissue may play a key role in the occurrence of vulnerable plaques. The identification of local perivascular inflammation may help identify patients who may benefit from targeted therapy.

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