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Abstract #4471

Study on Plasma BDNF Concentration and Rs-fMRI Characteristics Related to Motor Function

Yujie Lu1,2, Wenmei Li1, and Huiting Zhang3
1Radiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China, 2Radiology, ,Sichuan Cancer Hospital and Institute, Chengdu, China, 3Siemens Healthcare, Beijing, China


Results of our study showed that the level of plasma brain derived neurotrophic factor (BDNF) was positively correlated with cognitive function, and negatively correlated the changes in local brain network related to the destruction of motor and non-motor cortical areas in the hemispheres using rs-fMRI in capsular stroke (CS) group. Follow-up results demonstrated the mechanism of local dynamic network remodeling and its correlation with plasma BDNF concentration and clinical outcomes. It provides temporal and spatial information for the dynamic separation of brain networks in different stage of CS, and reflects the potential biological mechanism of proportional recovery.

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