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Abstract #4474

Compressed sensing improved the assessment of the corticospinal pathways in stroke brains scanned with traditional DTI

Yuguang Meng1 and Xiaodong Zhang1,2
1Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States, 2Division of Neuropharmacology and Neurologic Diseases, Yerkes National Primate Research Center, Emory Univeristy, Atlanta, GA, United States


Conventional diffusion tensor imaging (DTI) has been widely used to examine white matter connectivity with neurological diseases but is limited in detecting pathways with crossing fibers. As the crossing fibers are abundant in large and complicated brains like human and non-human primate brains, the DTI tractography results may be biased substantially. In stroke research, the integrity of corticospinal tract (CST) plays a critical role in assessing the motor function. In this study, a compressed sensing technique was explored to improve the CST delineation with conventional DTI, and the feasibility was evaluated by using a monkey model of stroke.

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