Liver biopsy and multi-parametric MRI/MRE were performed on 380 patients at risk of NASH. Histopathological diagnoses of NASH were collected along with proton density fat fraction (PDFF), and 3D-MRE measured liver stiffness (LS) and loss modulus (LM). While PDFF alone showed good ability to predict NASH (AUC: 0.80 [0.76, 0.85]), the addition of MRE measurements increased the diagnostic performance with strong statistical significance (AUC: 0.85 [0.81, 0.89], p<0.0004). LS alone was also found to be the strongest predictor of NASH-required treatment (AUC: 0.89 [0.84, 0.93], p<0.05), further establishing the critical role of MRE for clinical management of liver disease.
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