Diagnostic Performance of PDFF and Multi-Frequency 3D-MRE in the Detection of NASH and NASH-Required Therapy in a Large Cohort of 380 Patients
Kyle Kalutkiewicz1, Jiahui Li1, Zheng Zhu1, Jun Chen1, Taofic Mounajjed2, Kevin J. Glaser1, Safa Hoodeshenas1, Sudhakar K. Venkatesh1, Armando Manduca1, Claude B. Sirlin3, Vijay H. Shah4, Alina M. Allen4, Richard L. Ehman1, and Meng Yin1
1Radiology, Mayo Clinic, Rochester, MN, United States, 2Surgical Pathology, Mayo Clinic, Rochester, MN, United States, 3Radiology, UC San Diego, La Jolla, CA, United States, 4Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, United States
Liver biopsy and multi-parametric MRI/MRE were performed on 380 patients at risk of NASH. Histopathological diagnoses of NASH were collected along with proton density fat fraction (PDFF), and 3D-MRE measured liver stiffness (LS) and loss modulus (LM). While PDFF alone showed good ability to predict NASH (AUC: 0.80 [0.76, 0.85]), the addition of MRE measurements increased the diagnostic performance with strong statistical significance (AUC: 0.85 [0.81, 0.89], p<0.0004). LS alone was also found to be the strongest predictor of NASH-required treatment (AUC: 0.89 [0.84, 0.93], p<0.05), further establishing the critical role of MRE for clinical management of liver disease.
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