This study aimed to introduce a novel parameter—aorta (AO) global longitudinal strain (GLS)—for AO stiffness assessment by semi-automated feature tracking approach with standard cine cardiovascular magnetic resonance (CMR). The data demonstrated excellent intra and inter-observer variability of AO GLS of 4.4% and 5.0%, respectively. AO GLS was significantly negatively associated with age. The mean AO GLS was greater in females (10.1±3.5% versus 8.1±2.7%, P<0.001). The AO GLS decreased by 1.68% in females and 1.32% in males per decade respectively. Age was an independent predictor of the AO GLS in both males and females.
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