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Abstract #4557

Evaluation of cardiotoxicity in chest tumor patients receiving immune checkpoint inhibitors by cardiovascular magnetic resonance

Jia Liu1, Yukun Cao1, Kuikui Zhu1, Sheng Yao2, Mei Yuan1, Xiangchuang Kong1, Xiaoming Liu1, Yumin Li1, Yue Cui1, Xiaoyu Han1, Xiaoyue Zhou3, Rui Meng1, and Heshui Shi1
1wuhan union hospital, wuhan, China, 2wuhan tongji hospital, wuhan, China, 3Siemens Healthcare, shanghai, China


In our study, we conducted a prospective study to investigate the subclinical cardiotoxicity by serial cardiovascular magnetic resonance (CMR) in patients receiving immune checkpoint inhibitor (ICI). Some functional parameters and global strains of bi-ventricles revealed significant decrease at the early stage on ICI therapy, and ejection fraction as well as global strain values of both ventricles all showed a decline trend. Tissue characterization is an extra advantage of CMR technique. While in our study, parameters (T1 mapping, T2 mapping and late gadolinium enhancement) regarding tissue characterization of global myocardium showed no significant differences, compared with baseline data.

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