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Abstract #4587

The impact of hemodynamic patterns and geometric features of vertebra-basilar system on atherosclerotic plaque occurrence

Rui Shen1, Hualu Han1, Jinmei Zheng2, Huiyu Qiao1, Zihan Ning1, Xinyu Tong3, Yunjing Xue4, and Xihai Zhao1
1Center for Biomedical Imaging Research, Tsinghua University, Beijing, China, 2Fujian Medical University Union Hospital, Fuzhou, Fujian Province, China, 3Department of Biomedical Engineering, School of Life and Science, Beijing Institute of Technology, Beijing, China, 4Department of Radiology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China


This study investigated the relationship between the geometry of vertebra-basilar system and hemodynamic measurements and presence of BA plaques. We found that geometric measurements and most hemodynamic features were significantly correlated with the occurrence of BA plaque (mean curvature, r=0.368; NOR-TAWSS-NF, r=-0.312; SAR-OSI-NF, r=0.290; NOR-TAWSS-nNF, r=-0.387; NOR-OSI-nNF, r=0.440). There were significant differences in mean curvature, hemodynamic characteristics of Newtonian flow and non-Newtonian flow models between patients with and without BA plaque. Our study indicated that geometric features and non-Newtonian flow model-based hemodynamic measurements are risk factors of BA plaque.

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