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Abstract #4591

Altered Spontaneous Brain Activity Related to Neurologic Dysfunction in Patients with Cerebral Small Vessel Disease: A resting-state study

Mengmeng Feng1, Hongwei Wen2,3, Haotian Xin1, Changhu Liang4, and Lingfei Guo4
1Shandong Provincial Hospital, Jinan, China, 2Key Laboratory of Cognition and Personality (Ministry of Education), Chongqing, China, 3Southwest University, Chongqing, China, 4Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China


Cerebral small vessel disease (CSVD) patients can present structural and functional abnormalities. We divided 102 subjects into three groups and obtained information about altered spontaneous brain activity using amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF) and regional homogeneity (ReHo) methods based on resting-state functional MRI. Compared with controls and the CSVD without cerebral microbleeds (CSVD-n) group, the CSVD with cerebral microbleeds (CSVD-c) group showed significantly increased ALFF/ReHo values and decreased fALFF values in some brain regions, which are correlated to abnormal clinical characteristics. These results expounded the underlying neurophysiological mechanisms in CSVD patients.

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