Cerebral small vessel disease (CSVD) patients can present structural and functional abnormalities. We divided 102 subjects into three groups and obtained information about altered spontaneous brain activity using amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF) and regional homogeneity (ReHo) methods based on resting-state functional MRI. Compared with controls and the CSVD without cerebral microbleeds (CSVD-n) group, the CSVD with cerebral microbleeds (CSVD-c) group showed significantly increased ALFF/ReHo values and decreased fALFF values in some brain regions, which are correlated to abnormal clinical characteristics. These results expounded the underlying neurophysiological mechanisms in CSVD patients.
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