Repeatability and reliability of intravoxel incoherent motion derived parameters in evaluation of liver heterogeneity
Tianzhu Liu1, Weiyin Vivian Liu2, Jun Chen1, Lesheng Huang1, Hongyi Li1, Jinghua Jiang1, Kaili Cai1, Jiahui Tang1, Wanchun Zhang1, Kailian Yang1, Guangjun Tian3, Meng Hu3, Se Peng4, Dong Zhang3, Dong Zhang3, Dan Li3, and Yongxiang Zhuo3
1Radiology, Guangdong Hospital of Traditional Chinese Medicine, Zhuhai, Zhuhai, China, 2MR Research, GE Healthcare, Beijing, China, Beijing, China, 3Hepatology, Guangdong Hospital of Traditional Chinese Medicine, Zhuhai, Zhuhai, China, 4Laboratory, Guangdong Hospital of Traditional Chinese Medicine, Zhuhai, Zhuhai, China
This study aimed to investigate the repeatability and reliability of IVIM derived parameters in evaluation of liver heterogeneity. Patients with early liver fibrosis and healthy subjects were recruited and underwent MRI using respiratory triggered SS-DWI with 12 b values and an IDEAL-IQ sequence. Two readers independently analyzed liver segment data using mono-exponential, bi-exponential and stretched exponential models. CVs and ICCs were calculated before and after the exclusion of subjects with potential liver fat deposition. ADC, D and α measurements of right liver lobe were satisfactorily repeatable, regardless of fat deposition. Segment-VII and -VIII values may be more repeatable and reliable.
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