Abstract #4662

Repeatability and reliability of intravoxel incoherent motion derived parameters in evaluation of liver heterogeneity

Tianzhu Liu¹, Weiyin Vivian Liu², Jun Chen¹, Lesheng Huang¹, Hongyi Li¹, Jinghua Jiang¹, Kaili Cai¹, Jiahui Tang¹, Wanchun Zhang¹, Kailian Yang¹, Guangjun Tian³, Meng Hu³, Se Peng⁴, Dong Zhang³, Dong Zhang³, Dan Li³, and Yongxiang Zhuo³

¹Radiology, Guangdong Hospital of Traditional Chinese Medicine, Zhuhai, Zhuhai, China, ²MR Research, GE Healthcare, Beijing, China, Beijing, China, ³Hepatology, Guangdong Hospital of Traditional Chinese Medicine, Zhuhai, Zhuhai, China, ⁴Laboratory, Guangdong Hospital of Traditional Chinese Medicine, Zhuhai, Zhuhai, China

Synopsis

This study aimed to investigate the repeatability and reliability of IVIM derived parameters in evaluation of liver heterogeneity. Patients with early liver fibrosis and healthy subjects were recruited and underwent MRI using respiratory triggered SS-DWI with 12 b values and an IDEAL-IQ sequence. Two readers independently analyzed liver segment data using mono-exponential, bi-exponential and stretched exponential models. CVs and ICCs were calculated before and after the exclusion of subjects with potential liver fat deposition. ADC, D and α measurements of right liver lobe were satisfactorily repeatable, regardless of fat deposition. Segment-VII and -VIII values may be more repeatable and reliable.

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