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Abstract #4680

Regularized SUPER-CAIPIRINHA: accelerating 3D variable-flip-angle T1 mapping up to 16-fold with fast reconstruction

Fan Yang1, Jian Zhang2, Guobin Li2, Jiayu Zhu2, Xin Tang1, and Chenxi Hu1
1Institute of Medical Imaging Technology, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, 2United Imaging Healthcare Co., Ltd, Shanghai, China


Three-dimensional variable-flip-angle (VFA) T1 mapping is an accurate T1 quantification method suffering from long scan time. SUPER is a contrast-domain acceleration technique with strength in noise suppression and fast reconstruction. Here, we develop regularized SUPER-CAIPIRINHA to accelerate 3D VFA T1 mapping up to 16-fold with 10 flip angles, and perform fast reconstruction with the proposed proximal-Levenberg Marquardt algorithm. The novel method is validated with both retrospective and prospective experiments, compared to Locally Low Rank and Compressed Sensing. The results show that rSUPER-CAIPIRINHA is an accurate and computationally efficient technique, reducing the 3D scan time from 14:10 minutes to 0:59 minutes.

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