Metabolic timecourse of healthy aging
Tao Gong1,2, Steve C.N. Hui3,4, Helge J. Zöllner3,4, Mark Britton5,6,7, Yulu Song3,4, Aaron T. Gudmundson8, Kathleen Hupfeld9, Eric Porges5,6,7, Georg Oeltzschner3,4, Weibo Chen10, Guangbin Wang1,2, and Richard Edden3,4
1Departments of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, China, Jinan, China, 2Departments of Radiology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250021, China, Jinan, China, 3The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA, Baltimore, MD, United States, 4F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA, Baltimore, MD, United States, 5Center for Cognitive Aging and Memory, University of Florida, Gainesville, FL, USA, Gainesville, FL, United States, 6McKnight Brain Research Foundation, University of Florida, FL, USA, Gainesville, FL, United States, 7Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA, Gainesville, FL, United States, 8Department of Neurobiology and Behavior, University of California, Irvine,USA., Irvine, CA, United States, 9Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA, Gainesville, FL, United States, 10Philips Healthcare, Shanghai, China, Shanghai, CA, China
The metabolic timecourse of healthy aging is not well-established, in part due to diversity of quantification methodology. This study recruited a large structured cross-sectional cohort throughout adulthood to investigate metabolic changes as a function of age, and applied consensus-recommended quantification methods. Positive age correlations in tCho, tCr, and mI were observed for CSO and PCC, while none was found for tNAA, Glu or Glx in either region. PCC GABA decreased with age, CSO Scyllo increased, and we observed higher PCC Scyllo for female subjects. Our results establish a metabolic timecourse of healthy aging, as a normative foundation for future work.
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