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Abstract #4721

Differential association of apparent diffusion coefficient, apparent myelin water fraction, and T1w/T2w ratio in white matter and grey matter

Nan-Hao Chen1, Li-Ping Chen2, Chia-Wei Hsu2, Chin-Hua Yang1,2,3, and Hsu-Hsia Peng1
1Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan, 2National Taiwan University Hospital Hsinchu Branch, Hsinchu, Taiwan, 3Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan


The purpose of this study was to evaluate the differential associations among various myelin-related indices in white matter (WM) and grey matter (GM) to comprehend the alteration of microstructural integrity in brain tissue. We calculated mean, coefficient of variance (CV), and peak probability of ADC, apparent myelin water fraction (aMWF), and T1w/T2w ratio and found differential associations among myelin-related indices in GM and WM. In conclusion, measurements of ADC, aMWF, and T1w/T2w ratio as well as their correlations can help to understand characteristics of microstructural tissue integrity in GM and WM.

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