Time-dependent Diffusion in Extra-Axial Brain Tumors Investigated with Oscillating-gradient Spin-echo.
Tomoko Maekawa1, Masaaki Hori1,2, Katsutoshi Murata3, Thorsten Feiweier4, Kouhei Kamiya1,2, Christina Andica1, Akifumi Hagiwara1, Shohei Fujita1,5, Koji Kamagata1, Akihiko Wada1, and Shigeki Aoki1
1Radiology, Juntendo University School of Medicine, Tokyo, Japan, 2Radiology, Toho University Omori Medical Center, Tokyo, Japan, 3Siemens Healthcare K.K., Tokyo, Japan, 4Siemens Healthcare GmbH, Erlangen, Germany, 5Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
The purpose of our study was to investigate the utility of changes in diffusivity between short and long effective diffusion times (Δeff) in distinguishing extra-axial brain tumors. Patients with 12 meningiomas, 13 acoustic neuromas, and 11 pituitary adenomas were undergoing diffusion-weighted imaging with Δeff of 6.5 ms and 35.2 ms. The dependence of λ1, λ2, λ3, and MD values on Δeff was stronger in pituitary adenomas than in meningiomas and acoustic neuroma, suggesting differences in internal tissue structure. Our results showed that the use of DTI with shorter Δeff provides additional information about the microstructure of brain tumors.
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