Abstract #4723

Time-dependent Diffusion in Extra-Axial Brain Tumors Investigated with Oscillating-gradient Spin-echo.

Tomoko Maekawa¹, Masaaki Hori^1,2, Katsutoshi Murata³, Thorsten Feiweier⁴, Kouhei Kamiya^1,2, Christina Andica¹, Akifumi Hagiwara¹, Shohei Fujita^1,5, Koji Kamagata¹, Akihiko Wada¹, and Shigeki Aoki¹

¹Radiology, Juntendo University School of Medicine, Tokyo, Japan, ²Radiology, Toho University Omori Medical Center, Tokyo, Japan, ³Siemens Healthcare K.K., Tokyo, Japan, ⁴Siemens Healthcare GmbH, Erlangen, Germany, ⁵Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

Synopsis

The purpose of our study was to investigate the utility of changes in diffusivity between short and long effective diffusion times (Δ_eff) in distinguishing extra-axial brain tumors. Patients with 12 meningiomas, 13 acoustic neuromas, and 11 pituitary adenomas were undergoing diffusion-weighted imaging with Δ_eff of 6.5 ms and 35.2 ms. The dependence of λ1, λ2, λ3, and MD values on Δ_eff was stronger in pituitary adenomas than in meningiomas and acoustic neuroma, suggesting differences in internal tissue structure. Our results showed that the use of DTI with shorter Δ_eff provides additional information about the microstructure of brain tumors.

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