Abstract #4730

Assessment of renal injury in patients with IgA nephropathy using mono-exponential DWI vs IVIM derived from advanced zoomed-FOV DWI

Wei Mao¹, Xiaoqiang Ding², Caixia Fu³, Yuqin Ding¹, Thomas Benkert⁴, Robert Grimm⁴, Mengsu Zeng¹, and Jianjun Zhou¹

¹Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China, ²Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China, ³MR Application Development, Siemens Shenzhen Magnetic Resonance Ltd, Shenzhen, China, ⁴MR Application Predevelopment, Siemens Healthcare GmbH, Erlangen, Germany

Synopsis

The use of intravoxel incoherent motion (IVIM) and diffusion-weighted imaging (DWI) has increased for renal function and fibrosis assessments. However, debates have continued about which method is best. In this study, we used IVIM to assess the pathologic injury associated with IgA nephropathy and compared the results with the mono-exponential model of DWI. Both diffusion models were derived from advanced zoomed field of view (FOV) DWI acquisitions. IVIM had better diagnostic performance than the mono-exponential model in assessing the renal pathologic injury in patients with IgA nephropathy.

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