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Abstract #4730

Assessment of renal injury in patients with IgA nephropathy using mono-exponential DWI vs IVIM derived from advanced zoomed-FOV DWI

Wei Mao1, Xiaoqiang Ding2, Caixia Fu3, Yuqin Ding1, Thomas Benkert4, Robert Grimm4, Mengsu Zeng1, and Jianjun Zhou1
1Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China, 2Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China, 3MR Application Development, Siemens Shenzhen Magnetic Resonance Ltd, Shenzhen, China, 4MR Application Predevelopment, Siemens Healthcare GmbH, Erlangen, Germany

Synopsis

The use of intravoxel incoherent motion (IVIM) and diffusion-weighted imaging (DWI) has increased for renal function and fibrosis assessments. However, debates have continued about which method is best. In this study, we used IVIM to assess the pathologic injury associated with IgA nephropathy and compared the results with the mono-exponential model of DWI. Both diffusion models were derived from advanced zoomed field of view (FOV) DWI acquisitions. IVIM had better diagnostic performance than the mono-exponential model in assessing the renal pathologic injury in patients with IgA nephropathy.

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Abstract