A general framework to incorporate transcytolemmal water exchange in diffusion MRI-based microstructural imaging
Sisi Li1, Diwei Shi2, Li Chen2, Quanshui Zheng2, Hua Guo1, and Junzhong Xu3,4,5,6
1Center for Biomedical Imaging Research, Tsinghua University, Beijing, China, 2Center for Nano and Micro Mechanics, Department of Mechanics Engineering, Tsinghua University, Beijing, China, 3Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States, 4Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, 5Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, 6Department of Physics and Astronomy, Vanderbilt University, Nashville, TN, United States
Quantitative microstructural imaging based on diffusion MRI provides a non-invasive means to measure microstructural parameters, e.g., cell size. However, due to the remarkable complexity of incorporating transcytolemmal water exchange into diffusion biophysical models, water exchange is usually ignored. This leads to biased estimation of microstructural parameters, particularly intracellular volume fraction. Here, we propose a new approach to incorporate water exchange naturally in diffusion biophysical models with arbitrary gradient waveforms, making it possible to fit cell size, density, and intracellular water lifetime simultaneously. This establishes a general framework to incorporate transcytolemmal water exchange in any diffusion MRI-based microstructural imaging models.
This abstract and the presentation materials are available to members only;
a login is required.