Abstract #4757

Microstructural Basis of Fractional Anisotropy Difference Associated with b-value in Diffusion MRI

Junye Yao¹, Zihan Zhou¹, Benjamin C. Tendler², Karla L. Miller², Hao Lei³, Lei Zhang^4,5, Aimin Bao^4,5, Jianhui Zhong^1,6, and Hongjian He¹

¹Center for Brain Imaging Science and Technology, College of Biomedical Engineering and Instrumental, Zhejiang University, Hangzhou, China, ²Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, London, United Kingdom, ³State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan, China, ⁴Department of Neurology in Second Affiliated Hospital, Key Laboratory of Medical Neurobiology of Zhejiang Province, and Department of Neurobiology, Zhejiang University, Hangzhou, China, ⁵National Human Brain Bank for Health and Disease, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, China, ⁶Department of Imaging Sciences, University of Rochester, Rochester, NY, United States

Synopsis

The microstructural basis of b-value dependence on FA was investigated in the human brain, using in vivo MRI and a formalin-fixed human brain hemisphere. Consistent decreases of FA with increasing b-values were observed both in vivo and ex vivo. The percentage difference of FA (pdFA) between high and low b-value datasets was found to increase with neurite density estimated from NODDI, which was further validated using histology and a multi-compartment model simulation. Results indicate that the b-value dependence of FA can be explained by compartmental differences between intra- and extra-neurites.

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