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Abstract #4757

Microstructural Basis of Fractional Anisotropy Difference Associated with b-value in Diffusion MRI

Junye Yao1, Zihan Zhou1, Benjamin C. Tendler2, Karla L. Miller2, Hao Lei3, Lei Zhang4,5, Aimin Bao4,5, Jianhui Zhong1,6, and Hongjian He1
1Center for Brain Imaging Science and Technology, College of Biomedical Engineering and Instrumental, Zhejiang University, Hangzhou, China, 2Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, London, United Kingdom, 3State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan, China, 4Department of Neurology in Second Affiliated Hospital, Key Laboratory of Medical Neurobiology of Zhejiang Province, and Department of Neurobiology, Zhejiang University, Hangzhou, China, 5National Human Brain Bank for Health and Disease, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, China, 6Department of Imaging Sciences, University of Rochester, Rochester, NY, United States


The microstructural basis of b-value dependence on FA was investigated in the human brain, using in vivo MRI and a formalin-fixed human brain hemisphere. Consistent decreases of FA with increasing b-values were observed both in vivo and ex vivo. The percentage difference of FA (pdFA) between high and low b-value datasets was found to increase with neurite density estimated from NODDI, which was further validated using histology and a multi-compartment model simulation. Results indicate that the b-value dependence of FA can be explained by compartmental differences between intra- and extra-neurites.

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