Abstract #4759

Intra-hippocampal fiber tracking and connectome from submillimeter DTI of the human hippocampus in vivo and ex vivo

Yixin Ma^1,2, Trong-Kha Truong^1,2,3, Iain P. Bruce^1,4, Alexandra Badea^1,2,3,4, Simon Davis⁴, Chun-Hung Yeh⁵, Jeffrey R. Petrella^1,2,3, and Allen W. Song^1,2,3

¹Brain Imaging and Analysis Center, Duke University, Durham, NC, United States, ²Medical Physics Graduate Program, Duke University, Durham, NC, United States, ³Department of Radiology, Duke University, Durham, NC, United States, ⁴Department of Neurology, Duke University, Durham, NC, United States, ⁵Institute for Radiological Research, Chang Gung University and Chang Gung Memorial Hospital, Taoyuan, Taiwan

Synopsis

The hippocampus plays an essential role in memory; the impairment in intra-hippocampal connectivity could result in memory loss in neurodegenerative dementias. We generate intra-hippocampal fiber tracts and connectomes from submillimeter isotropic DTI images for repeated scans from the same subjects and across different subjects. We characterize the fiber orientations and connectivity across hippocampal subfields by registering all in vivo scans onto the population template and we compare these results with those from an ex vivo human brain sample. This method can assess intra-hippocampal connectivity in vivo, which could be potentially used to diagnose neurodegenerative diseases.

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