Abstract #4774

Cardiac Quantitative Susceptibility Mapping for Mitral Annular Calcium: Validation using Quantitative Calcium Scoring on Computed Tomography

Pablo Villar-Calle¹, Jiahao Li², Alice Saffioti¹, Justin Johannesen¹, Katherine Tak¹, Rachel Meier¹, Jiwon Kim¹, Quynh A Truong³, Yi Wang², Pascal Spincemaille³, and Jonathan W Weinsaft¹

¹Medicine, Weill Cornell Medicine, New York NY, United States, New York, NY, United States, ²Meinig School of Biomedical Engineering, Cornell University, Ithaca NY, United States, New York, NY, United States, ³Radiology, Weill Cornell Medicine, New York NY, United States, New York, NY, United States

Synopsis

This study tested cardiac MRI cardiac quantitative susceptibility mapping (QSM) for measurement of mitral annular calcification (MAC) using the reference of computed tomography (CT). QSM entailed a free-breathing ECG-triggered multi-echo 3D GRE sequence with diaphragmatic navigation via ECG-gating (1D respiratory navigator, 4mm window, acquisition time ~7 minutes, navigator efficiency 36%, spatial resolution 1.5×1.5×5mm3). Among 24 patients undergoing MRI and CT (mean 3.9±3.4 months), annular susceptibility decreased stepwise (p<0.001) and R2* increased (p<0.05) among patients stratified by CT mitral annular calcium score. Both QSM (AUC=0.950, p=0.005) and R2* (AUC=0.938, p=0.007) yielded excellent diagnostic performance for advanced mitral annular calcification on CT.

This abstract and the presentation materials are available to members only; a login is required.

Join Here