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Abstract #4789

Quantification of in-vivo myocardial stiffness in the rat heart using transient mechanical waves

Marco Barbero Mota1, Giacomo Annio1, Guillaume Rucher2, Anna Wittgestein3, David Nordsletten3,4, Jordi Martorell5, and Ralph Sinkus1,3
1LVTS U1148, LVTS U1148 INSERM - Université de Paris, Paris, France, 2FRIM, INSERM - Université de Paris, Paris, France, 3School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 4Biomedical Engineering and Cardiac Surgery, University of Michigan, Ann Arbour, MI, United States, 5Chemical Engineering, IQS, Barcelona, Spain


Heart biomechanics play a crucial role in the diagnosis and prognosis of cardiac diseases. However, current gold standard methods are highly invasive and preclude continuous monitoring of patients’ myocardium stiffness as a biomarker. In this study, we report the first results of a novel magnetic resonance elastography technique that provides with high temporal and spatial resolution enabling accurate transient shear wave speed values quantification, as thereof travel through heart tissue. Although biased due to the thin-plate geometry of the heart, early and mid-late systole, and early diastole preliminary results intuitively match the expected dynamical biomechanics of the human heart.

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