Brain microstructural changes in stroke patients at subacute/chronic stages by mean of advanced diffusion MRI: a longitudinal study
Shi-Ming Wang1, Guglielmo Genovese2,3,4, Belen Diaz3,5, Fan Huang6, Stéphane Lehericy2,3, Hui Zhang1, Charlotte Rosso3,5, Francesca Branzoli2,3, and Marco Palombo1,7,8
1Centre for Medical Image Computing (CMIC), Department of Computer Science, University College London, London, United Kingdom, 2Paris Brain Institute - ICM, Centre de NeuroImagerie de Recherche - CENIR, Paris, France, 3Sorbonne Université, UMR S 1127, Inserm U 1127, CNRS UMR 7225, ICM, F-75013, Paris, France, 4Center for Magnetic Resonance Research and Department of Radiology, University of Minnesota, Minneapolis, MN, United States, 5Department of Neurology, Pitié-Salpétrière Hospital, Paris, France, 6Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, 7Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom, 8School of Computer Science and Informatics, Cardiff University, Cardiff, United Kingdom
This study characterises microstructural changes in stroke lesions using NODDI and WMTI, two advanced diffusion MRI techniques, and compares their ability to detect WM alterations on the ipsi-lesional and contralesional sides of 12 patients scanned 2 weeks, 1 month and 3 months after onset. Region-of-interest analysis showed that ODI and FWF from NODDI were significantly altered at the lesion. Significant changes were also found in the WMTI parameters of several ipsi-lesional white matter tracts. Our prospective analysis suggests that the application of enhanced dMRI methods such as NODDI and WMTI can help to further comprehend the biophysical mechanism behind ischemia.
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