Abstract #4793

Brain microstructural changes in stroke patients at subacute/chronic stages by mean of advanced diffusion MRI: a longitudinal study

Shi-Ming Wang¹, Guglielmo Genovese^2,3,4, Belen Diaz^3,5, Fan Huang⁶, Stéphane Lehericy^2,3, Hui Zhang¹, Charlotte Rosso^3,5, Francesca Branzoli^2,3, and Marco Palombo^1,7,8

¹Centre for Medical Image Computing (CMIC), Department of Computer Science, University College London, London, United Kingdom, ²Paris Brain Institute - ICM, Centre de NeuroImagerie de Recherche - CENIR, Paris, France, ³Sorbonne Université, UMR S 1127, Inserm U 1127, CNRS UMR 7225, ICM, F-75013, Paris, France, ⁴Center for Magnetic Resonance Research and Department of Radiology, University of Minnesota, Minneapolis, MN, United States, ⁵Department of Neurology, Pitié-Salpétrière Hospital, Paris, France, ⁶Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, ⁷Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom, ⁸School of Computer Science and Informatics, Cardiff University, Cardiff, United Kingdom

Synopsis

This study characterises microstructural changes in stroke lesions using NODDI and WMTI, two advanced diffusion MRI techniques, and compares their ability to detect WM alterations on the ipsi-lesional and contralesional sides of 12 patients scanned 2 weeks, 1 month and 3 months after onset. Region-of-interest analysis showed that ODI and FWF from NODDI were significantly altered at the lesion. Significant changes were also found in the WMTI parameters of several ipsi-lesional white matter tracts. Our prospective analysis suggests that the application of enhanced dMRI methods such as NODDI and WMTI can help to further comprehend the biophysical mechanism behind ischemia.

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