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Abstract #4802

Optimal experimental design of MR Fingerprinting for simultaneous quantification of T1, T2, and ADC

Siyuan Hu1, Debra McGivney1, Mark Griswold2, and Dan Ma1
1Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, 2Radiology, Case Western Reserve University, Cleveland, OH, United States


The MRF framework has been recently investigated to estimate T1, T2 and apparent diffusion coefficient (ADC) from a single scan with b-tensor encoding schemes. However, the current human-designed experiment protocol for multi-dimensional MRF is still subject to limited measurement accuracy. Here we propose to adapt the Cramer-Rao Bounds to optimize multi-dimensional MRF scan for simultaneous quantification of relaxation and diffusion. The optimization framework explores all possible combinations of MRF sequence parameters, including flip angles, TRs, b-values, and preparation modules to seek the optimal tissue parameter encoding scheme. The optimized sequence simultaneously improves the measurement precision of T1, T2 and ADC.

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