Hyperthermia refers to a cancer treatment by elevating tissue temperature to 40-45 °C. Hyperthermia can be achieved by clinical MRgFUS system, allowing real-time temperature monitoring for the precise control of hyperthermia heating. Currently the ExAblate is MR-guided FUS ablation system with the largest installation worldwide, however, requires advanced beamforming strategies for volumetric hyperthermia. This study proposed electronic beam steering, multi-focal patterns, and sector-vortex beamforming approaches in conjunction with partial array activation and was evaluated in biothermal simulations and phantom experiments. This study demonstrated the feasibility of sustained large volume heating with MR thermometry feedback using the ExAblate body system.
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