Abstract #4829

QSM as a Potential Treatment Efficacy Indicator for MR-HIFU-mediated Histotripsy

Johannes Lindemeyer¹, Lukas Christian Sebeke¹, Ari Partanen², Christian Lucas Haas¹, and Holger Grüll^1,3

¹Department of Diagnostic and Interventional Radiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany, ²Profound Medical Inc, Mississauga, ON, Canada, ³Department of Chemistry, Faculty of Mathematics and Natural Sciences, University of Cologne, Cologne, Germany

Synopsis

High intensity focused ultrasound-mediated histotripsy is a modality for targeted, non-invasive interventions. As temperature changes detected by MR-thermometry are not directly related to histotripsy treatment success, we propose quantitative susceptibility mapping (QSM) to evaluate and monitor treatment efficacy. Fresh porcine heart muscle tissue was sonicated using a clinical MR-HIFU system. Herein, we demonstrate the successful visualization of histotripsy-induced lesions by QSM.

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