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Abstract #4829

QSM as a Potential Treatment Efficacy Indicator for MR-HIFU-mediated Histotripsy

Johannes Lindemeyer1, Lukas Christian Sebeke1, Ari Partanen2, Christian Lucas Haas1, and Holger Grüll1,3
1Department of Diagnostic and Interventional Radiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany, 2Profound Medical Inc, Mississauga, ON, Canada, 3Department of Chemistry, Faculty of Mathematics and Natural Sciences, University of Cologne, Cologne, Germany


High intensity focused ultrasound-mediated histotripsy is a modality for targeted, non-invasive interventions. As temperature changes detected by MR-thermometry are not directly related to histotripsy treatment success, we propose quantitative susceptibility mapping (QSM) to evaluate and monitor treatment efficacy. Fresh porcine heart muscle tissue was sonicated using a clinical MR-HIFU system. Herein, we demonstrate the successful visualization of histotripsy-induced lesions by QSM.

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