Atlas based MRI investigations involving PD-weighted (PDw), T2-weighted (T2w) MRI sequences on older adults typically utilized younger adult templates such as those of the ICBM. Additionally, a thorough quantitative assessment of how available standardized PDw and T2w templates perform on aging population has not yet been performed. Here a new standardized high resolution PDw, T2w and T2 map templates of the MIITRA atlas dedicated for studies on older adults was developed using concepts of super-resolution and sparse-representation and compared to other available standardized templates in terms of image quality, inter-subject spatial normalization accuracy and representativeness of the older adult brain.
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