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Abstract #4833

Development of high resolution PD-weighted, T2-weighted, and T2 map templates for use in studies on older adults.

ABDUR RAQUIB RIDWAN1, Mohammad Rakeen Niaz1, Yingjuan Wu1, Shengwei Zhang2, David A. Bennett2, and Konstantinos Arfanakis1,2
1Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States, 2Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, United States


Atlas based MRI investigations involving PD-weighted (PDw), T2-weighted (T2w) MRI sequences on older adults typically utilized younger adult templates such as those of the ICBM. Additionally, a thorough quantitative assessment of how available standardized PDw and T2w templates perform on aging population has not yet been performed. Here a new standardized high resolution PDw, T2w and T2 map templates of the MIITRA atlas dedicated for studies on older adults was developed using concepts of super-resolution and sparse-representation and compared to other available standardized templates in terms of image quality, inter-subject spatial normalization accuracy and representativeness of the older adult brain.

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