Improved Structural Neuro-MRI with Triple TSE-based Synthetic MP-RAGE
Lei Zhang1, Ryan McNaughton2, Hernan Jara2, David N. Kennedy3, Carmen A. Marable1, Ning Hua4, Karl C. K. Kuban4, T. Michael O'Shea1, and Rebecca C. Fry1
1University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, 2Boston University, Boston, MA, United States, 3University of Massachusetts Chan Medical School, Worcester, MA, United States, 4Boston University Medical Center, Boston, MA, United States
Purpose: To develop and evaluate a metal-artifact robust triple turbo-spin-echo (TSE)-based synthetic MP-RAGE method. Methods: T1, T2 and PD maps generated from triple TSE, two MP-RAGE image sets simulated by the Bloch equation, and FreeSurfer brain segmentation were performed on 44 participants at age of fifteen. Results: Reduced artifact and homogenous synthetic MP-RAGE images were produced in orthodontic brace-wearing subjects. Comparable image contrast and FreeSurfer brain segmentation results were observed between synthetic and acquired MP-RAGE in normal subjects. Conclusion: Triple TSE based synthetic MP-RAGE may enhance conventional MP-RAGE in the neuroimaging studies of orthodontic brace-wearing subjects with reduced metal artifacts.
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