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Abstract #4849

Quantitative Mapping of Brain Tissue Oxygenation around chronically implanted neural interfaces

Yuka Sugamura1, Arati Sridharan1, Umu Jalloh1, Babak Moghadas1, Livia De Mesquita Teixeira1, Jitendran Muthuswamy1, and Vikram Kodibagkar1
1Arizona State University, Tempe, AZ, United States


Chronic implantation of neural interfaces often experiences decrease in signal reliability over time. Tissue response, including the alteration of the oxygen kinetics, is thought to be a major cause. Here, we report the spatial mapping of brain oxygenation around chronically implanted electrodes using a previously developed quantitative MRI-based oxygen sensing technique, PISTOL. Seven 200 um diameter electrodes implanted in four mice allowed quantitative pO2 mapping throughout the 7-week study. No changes were observed in the baseline brain tissue oxygenation as well as the response to respiratory challenge. Future studies will combine this approach with electrophysiology, and ultimately perform simultaneous assessment.

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