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Abstract #4863

Dynamic Contrast Enhanced (DCE) MRI of the Abdominal Aortic Aneurysm (AAA) Wall

Ang Zhou1, Huiming Dong1, Joseph Leach1, Chengcheng Zhu2, David Saloner1, Michael Hope1, and Dimitrios Mitsouras1
1Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, 2Department of Radiology, University of Washington, Seattle, WA, United States


Abdominal Aortic Aneurysms (AAAs) are common in older men. Guidelines recommend repair at an aneurysm diameter greater than 5.5 cm, but some smaller aneurysms experience catastrophic rupture. Aneurysm features beyond diameter have been explored as markers of disease progression. We used DCE MRI to explore the inhomogeneity of contrast kinetics, including Ktrans, in the aneurysm wall and assess if these markers independently predict AAA progression. Significant differences in DCE metrics were identified around the AAA circumference. Area under enhancement-time curve and enhancement slope correlated with growth rate but not diameter, suggesting that DCE may provide diameter-independent information regarding AAA risk.

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