Abstract #4866

Validation of Qp/Qs quantification based on 4D flow MRI: effects of scan acceleration techniques

Takashi Fujiwara¹, Erin K Englund¹, Mehdi H Moghari¹, Brian Fonseca², Lorna P Browne¹, and Alex J Barker^1,3

¹Department of Radiology, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus, Aurora, CO, United States, ²Department of Pediatrics, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus, Aurora, CO, United States, ³Department of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, CO, United States

Synopsis

The ratio of pulmonary to systemic blood flow (Qp/Qs) is a clinically important index to estimate the existence and amount of cardiovascular shunt flow and to determine the need for surgical intervention for congenital heart disease patients. Accelerated 4D flow MRI is capable of measuring Qp/Qs in a single acquisition, but its accuracy and reliability are not well established. We compared conventional 2D phase-contrast MRI and two 4D flow MRI acquisitions with different acceleration techniques to investigate accuracy of Qp/Qs quantification with accelerated 4D flow in adult healthy volunteers (N=10). Consequently, we found no statistical differences in Qp/Qs.

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