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Abstract #4877

Mapping the Age Effect on Cortical Arterial Arrival Time and Perfusion using multi-delay pCASL

Yutong Sun1, Paul T.H Chang 1, and J. Jean Chen2
1Rotman Research Institute, Baycrest Health Sciences, Toronto, ON, Canada, 2Medical Biophysics, University of Toronto, Toronto, ON, Canada


Multi-delay arterial spin labeling (ASL) has made it possible to non-invasively quantify cerebral hemodynamic changes in aging, including cerebral blood flow (CBF) and arterial arrival time (ATT). However, limited numbers of studies exist to focus on the spatial heterogeneity of age effects on both CBF and ATT. In this study, we map the relationships between age, CBF and ATT on the cerebral cortex using multi-delay pseudo-continuous ASL (pCASL) data from the Human Connectome Project in Aging.

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