Arterial spin labeled (ASL) MRI is often acquired at reduced spatial resolution due to lower signal to noise (SNR), although higher spatial resolution within clinically feasible scan times is desired. In this study, we applied Compressed Sensing–Sensitivity Encoding (CS-SENSE) to 3D Cartesian TSE with Variable Density (VD) sampling to achieve higher spatial resolution ASL-MRI without prolonging acquisition time. Perfusion images acquired with CS-SENSE showed good SNR and image quality in both brains and kidneys, without introducing bias to perfusion quantification. This may be particularly useful to measure perfusion changes in small-sized lesions in both brains and kidneys.
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