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Abstract #4896

Vessel Density Mapping of Brain Small Vessels on 3D High Resolution Black Blood MRI

Mona Sharifi Sarabi1, Samantha J Ma1,2, Danny JJ Wang1, and Yonggang Shi1
1University of Southern California, Los Angeles, CA, United States, 2Siemens Medical Solutions USA, Inc., Los Angeles, CA, United States


High resolution 3D black blood MRI with sub-millimeter spatial resolution has been proposed for visualizing small vessels of the brain. Here we present and evaluate a novel approach for mapping brain vessel density from 3D black blood images acquired at 3T. Using automated vessel segmentation and non-linear registration, localized detection and quantification of small vessel density is demonstrated to be feasible. This framework can potentially serve as a useful tool for detection and monitoring of localized vascular changes in aging and neurovascular disorders.

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